China Sinopharm International (Shanghai) Co., Ltd.  

Product Name: High Quality 99.9% Ampicillin for USP Ep Cep CAS 69-53-4 Model NO.: Ampicillin Volatile: Not Volatile State: Solid Type: Analysis reagent Grade Standard: Medicine Grade Certification: GMP, Reach, FDA, USP Ep Function: Antibiotic and Antimicrobial Agents Powder: Yes Customized: Customized Suitable for: Elderly, Children, Adult Purity: >99% Trademark: China Sinopharm Transport Package: 25 Kg/Drum Specification: 25 KG/drum Origin: China HS Code: 2900 Product Description High Quality 99.9% Ampicillin for USP Ep Cep CAS 69-53-4Ampicillinis anantibioticused to prevent and treat a number ofbacterial infections, such asrespiratory tract infections,urinary tract infections,meningitis,salmonellosis, andendocarditis. It may also be used to preventgroup B streptococcal infectionin newborns.It is used by mouth, byinjection into a muscle, or intravenously.Like all antibiotics, it is not useful for the treatment of viral infections.Product Name:Ampicillin PowderTest:HPLCCAS:7177-48-2Active Ingredient:AmpicillinCertificate:GMP ISO USP BpGrade Standard:Feed Grade, Food Grade, Medicine GradeType of Product:Auxiliaries and Other Medicinal ChemicalsShelf Life:2 Years Proper StorageTransport Package:1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per DrumSpecification99% min Tetramisole HClMfC16H19N3O4SMW403.5InteractionsAmpicillin reacts withprobenecidandmethotrexateto decreaserenal excretion. Large doses of ampicillin can increase the risk of bleeding with concurrent use ofwarfarinand other oral anticoagulants, possibly by inhibiting platelet aggregation.Ampicillin has been said to makeoral contraceptivesless effective,but this has been disputed.It can be made less effective by other antibiotic, such aschloramphenicol,erythromycin,cephalosporins, andtetracyclines.For example, tetracyclines inhibit protein synthesis in bacteria, reducing the target against which ampicillin acts.If given at the same time as aminoglycosides, it can bind to it and inactivate it. When administered separately, aminoglycosides and ampicillin can potentiate each other instead.Ampicillin causes skin rashes more often when given withallopurinol.Both the live cholera vaccine and live typhoid vaccine can be made ineffective if given with ampicillin. Ampicillin is normally used to treat cholera and typhoid fever, lowering the immunological response that the body has to mount.Mechanism of actionThe amino group (highlighted in magenta) is present on ampicillin but notpenicillin G.Ampicillin is in thepenicillingroup ofbeta-lactam antibioticsand is part of theaminopenicillinfamily. It is roughly equivalent toamoxicillinin terms of activity.Ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. It differs frompenicillin G, or benzylpenicillin, only by the presence of anaminogroup. This amino group, present on both ampicillin and amoxicillin, helps these antibiotics pass through the pores of the outer membrane of Gram-negative bacteria, such asE. coli,Proteus mirabilis,Salmonella enterica, andShigella.Ampicillin acts as an irreversible inhibitor of the enzymetranspeptidase, which is needed by bacteria to make the cell wall.It inhibits the third and final stage of bacterial cell wall synthesis inbinary fission, which ultimately leads to celllysis; therefore, ampicillin is usually bacteriolytic.PharmacokineticsAmpicillin is well-absorbed from theGI tract(though food reduces its absorption), and reaches peak concentrations in one to two hours. Thebioavailabilityis around 62% for parenteral routes. Unlike other penicillins, which usually have bind 60-90% toplasma proteins, ampicillin binds to only 15-20%.Ampicillin is distributed through most tissues, though it is concentrated in the liver and kidneys. It can also be found in thecerebrospinal fluidwhen the meninges become inflamed (such as, for example, meningitis).Some ampicillin is metabolized by hydrolyzing the beta-lactam ring topenicilloic acid,though most of it is excreted unchanged.In the kidneys, it is filtered out mostly bytubular secretion; some also undergoesglomerular filtration, and the rest is excreted in thefecesandbile.Hetacillinandpivampicillinare ampicillinestersthat have been developed to increase bioavailability.